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The LO participates in the free radical chain reaction, destroys the adjacent PUFAs directly, and causes cell membrane damage and ferroptosis ( With Fe 2+ , Fenton reaction converts hydrogen peroxide (H 2 O 2 ) to OH radicals, which propagate free radical chain reactions (Figure 2B)

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In comparison, the more prominent enriched pathways for Low weight loss responders included those related to amino acid and peptide metabolism (glycine, serine, and threonine, d-glutamine and d-glutamate, and tyrosine metabolism and arginine biosynthesis